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Image Search Results
Journal: Nutrients
Article Title: The Clinical Effect of a Propolis and Mangosteen Extract Complex in Subjects with Gingivitis: A Randomized, Double-Blind, and Placebo-Controlled Clinical Trial
doi: 10.3390/nu16173000
Figure Lengend Snippet: Biomarkers in gingival crevicular fluid by measurement time in the PP set.
Article Snippet: The concentrations of IL-1β, PGE2, MMP-8, and MMP-9 in gingival crevicular fluid (GCF) were quantified using enzyme-linked
Techniques: Control
Journal: Nutrients
Article Title: The Clinical Effect of a Propolis and Mangosteen Extract Complex in Subjects with Gingivitis: A Randomized, Double-Blind, and Placebo-Controlled Clinical Trial
doi: 10.3390/nu16173000
Figure Lengend Snippet: Biomarkers in gingival crevicular fluid by measurement time in the FA set.
Article Snippet: The concentrations of IL-1β, PGE2, MMP-8, and MMP-9 in gingival crevicular fluid (GCF) were quantified using enzyme-linked
Techniques: Control
Journal: Nutrients
Article Title: The Clinical Effect of a Propolis and Mangosteen Extract Complex in Subjects with Gingivitis: A Randomized, Double-Blind, and Placebo-Controlled Clinical Trial
doi: 10.3390/nu16173000
Figure Lengend Snippet: Proposed mechanism of propolis–mangosteen extract complex (PMEC) in mitigating periodontal tissue destruction. PMEC exhibits inhibitory effects on the expression of pro-inflammatory cytokines (IL-1β and PGE2) and metalloproteases (MMP-8 and MMP-9) in oral bacterial-infected periodontal tissue cells, including neutrophils, macrophages, and gingival fibroblasts. This inhibition potentially leads to decreased osteoclastogenesis and enhanced osteogenesis, consequently reducing alveolar bone destruction. However, PMEC does not prevent the direct invasion of periodontal pathogens into gingival tissue cells or the subsequent release of lipopolysaccharides (LPSs) and exotoxins into gingival capillaries. This limitation may explain the discrepancy between clinical parameter outcomes in PMEC treatment and placebo groups, despite significant reductions in gingival crevicular fluid biomarkers (IL-1β, PGE2, MMP-8, and MMP-9) observed in PMEC-treated subjects compared to controls.
Article Snippet: The concentrations of IL-1β, PGE2, MMP-8, and MMP-9 in gingival crevicular fluid (GCF) were quantified using enzyme-linked
Techniques: Expressing, Infection, Inhibition